CBD for Arthritis Pain: What You Should Know
Learn what the science says about the risks and benefits of CBD use for arthritis and what to shop for.
Updated Sept. 14, 2022
CBD Overview
What is CBD? CBD, short for cannabidiol, is an active compound found in the cannabis plant. CBD will not get you high but may cause some drowsiness for some people. The CBD in most products is extracted from hemp, a variety of cannabis. Legally, CBD products may have up to 0.3% of THC, the active compound that gets people high.
Does CBD help with arthritis? Animal studies have suggested that CBD has pain-relieving and anti-inflammatory properties, but these effects have not been validated in quality studies in humans. Anecdotally, some people with arthritis who have tried CBD report noticeable pain relief, sleep improvement and/or anxiety reduction. However, like any medication for arthritis, some people do not report any symptom improvements when taking CBD.
Is CBD safe to use? Research evaluating the safety of CBD is underway. At this point very little is known about CBD use among people with arthritis. So far, no serious safety concerns have been associated with moderate doses. CBD is thought to have the potential to interact with some drugs commonly taken by people with arthritis. Talk to your doctor before trying CBD if you take any of the following: corticosteroids (such as prednisone), tofacitinib (Xeljanz), naproxen (Aleve), celecoxib (Celebrex), tramadol (Ultram), certain antidepressants, including amitriptyline (Elavil), citalopram (Celexa), fluoxetine (Prozac), mirtazapine (Remeron), paroxetine (Paxil), sertraline (Zoloft), and certain medications for fibromyalgia, including gabapentin (Neurontin) and pregabalin (Lyrica). In addition, CBD products can have up to .3% of THC by weight — not by dose — so taking too much of a product may still cause THC-type effects.
Are CBD products legal? CBD products made from hemp are no longer considered Schedule I drugs under the federal Controlled Substances Act, but they still remain in a legal gray zone. While you can legally purchase CBD products in nearly every state and online, their legal status may ultimately change at the state and federal level depending on how laws and regulations are developed and enforced. For example, a recent paper in JAMA Psychiatry reported that people taking a legal CBD product still had measurable quantities of THC in their urine, which could have employment repercussions. People who want to use CBD should check their state laws.
Taking the First Step
Should I give CBD a try? Without quality clinical studies on CBD and arthritis, doctors have not been able to say who might benefit from CBD, at what dose and in which form, who likely won’t benefit, and who should avoid it. Still, there is agreement on several points:
What type of product should I consider? CBD-based products can be taken orally, applied to the skin or inhaled. There are pros and cons for each.
By mouth. CBD that is swallowed, whether in capsules, food or liquid, is absorbed through the digestive tract. Absorption is slow and dosing is tricky due to the delayed onset of effect (one to three hours), unknown effects of stomach acids, recent meals and other factors.
Capsules can work for daily use after a safe, effective dose has been established. Experts discourage taking CBD via edibles, like gummies and cookies, because dosing is unreliable, sugar can be inflammatory, and they are appealing to children but do not come in childproof containers. Like any medicine, edibles should be secured out of sight and reach of children.
CBD can also be absorbed directly into the bloodstream by holding liquid from a spray or tincture (a liquid dosed by a dropper) under the tongue (sublingual) for 60 to 120 seconds. The taste may not be pleasant. Effects may be felt within 15 to 45 minutes. If sprays or tinctures are swallowed, their effects tend to be similar to capsules or edibles.
On the skin. Topical products, like lotions and balms, are applied to the skin over a painful joint. Whether these products deliver CBD below the skin is unknown. Topical products may also include common over-the-counter ingredients such as menthol, capsaicin or camphor, making it difficult to determine if a positive effect is due to the CBD or another ingredient.
Inhaled. CBD can be inhaled via a vaporizing, or vape, pen. However, inhalation of vapor oils and chemical byproducts carry unknown risks, particularly for people with inflammatory arthritis. Some vaping products, especially those purchased online rather than from state-licensed dispensaries, may also contain chemicals (such as Vitamin E acetate) that may cause severe pulmonary disease. As such, vaping should be approached with caution and is typically not recommended.
How much CBD should I use? While there are no established clinical guidelines, the medical experts consulted by the Arthritis Foundation recommend the following for adults:
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What to Look for When Shopping
There is good reason to be a cautious shopper. CBD products are largely unregulated in the U.S. market. Independent testing has shown mislabeling and lack of quality control. The biggest issues are strength of CBD (significantly more or less than the label says), the presence of undeclared THC, and contamination with pesticides, metals and solvents. Here’s what to look for:
Our gratitude to the following experts for their guidance and review:
Kevin Boehnke, PhD, a researcher at the Chronic Pain and Fatigue Research Center at the University of Michigan, focuses on medical cannabis as an analgesic and opioid substitute in chronic pain.
Daniel Clauw, MD, a professor of anesthesiology, rheumatology and psychiatry at the University of Michigan and director of the Chronic Pain and Fatigue Research Center, leads research on arthritis pain and fibromyalgia, and the effects of cannabis, particularly CBD, in pain.
Mary-Ann Fitzcharles, MD, an associate professor of medicine in the Division of Rheumatology at McGill University in Montreal, Quebec, conducts research on pain and rheumatic diseases. She is the lead author of the 2019 Canadian Rheumatology Association (CRA) position statement for medical cannabis.
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